100872-83-1

• 

• Basic information

  1. Product Name: ML346
  2. Synonyms: ML346
  3. CAS NO:100872-83-1
  4. Molecular Formula: C14H12N2O4
  5. Molecular Weight: 272.25608
  6. EINECS: 604-604-1
  7. Product Categories: N/A
  8. Mol File: 100872-83-1.mol

• Chemical Properties

  1. Melting Point: 266-268 °C(Solv: ethyl acetate (141-78-6))
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: 1.374±0.06 g/cm3(Predicted)
  6. Refractive Index: N/A
  7. Storage Temp.: N/A
  8. Solubility: N/A
  9. PKA: 7.42±0.20(Predicted)
  10. CAS DataBase Reference: ML346(CAS DataBase Reference)
  11. NIST Chemistry Reference: ML346(100872-83-1)
  12. EPA Substance Registry System: ML346(100872-83-1)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 100872-83-1(Hazardous Substances Data)

• Suppliers
• Usage
• SDS
• Upstream product
• Downstream Products
• Article

100872-83-1 Suppliers

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• ML346

  Cas No: 100872-83-1

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• 10 Milligram

• Amadis Chemical Co., Ltd.
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• ML346

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• 1 Kilogram

• 10 Metric Ton/Month

• NANJING SUNNY PHARMATECH CO., LTD
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• 5-[(2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-1,3-diazinane-2,4,6-trione

  Cas No: 100872-83-1

• USD $ 1.9-2.9 / Gram

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• ML346

  Cas No: 100872-83-1

• USD $ 10.0-10.0 / Milligram

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• weifang yangxu group co.,ltd
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• ML346

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• LIDE PHARMACEUTICALS LIMITED
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• ML346

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• Shanghai Yuanye Bio-Technology Co., Ltd.
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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• tianjin kailiqi biotechnology co.，ltd
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• Nanjing Chemlin Chemical Co., Ltd.
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100872-83-1 Usage

Uses

Used in Pharmaceutical Industry:
ML346 is used as a therapeutic agent for the treatment of neurodegenerative diseases, such as Huntington's disease, by reducing aggregate formation in cellular models expressing human Huntingtin exon 1 with a 74 glutamine expansion at a concentration of 10 μM.
Used in Genetic Disorder Treatment:
ML346 is used as a treatment for cystic fibrosis, particularly for patients carrying the F508 deletion (ΔF508-CFTR) mutation. It helps correct the trafficking of the cystic fibrosis transmembrane conductance regulator proteins, leading to increased cell surface expression and improved functionality.
Used in Cellular Protection:
ML346 is used as a protective agent in cell cultures, particularly in mouse embryonic fibroblasts (MEFs), to prevent severe heat shock-induced death and H2O2-induced apoptosis by inducing the expression of heat shock proteins and oxidative stress response genes.
Used in Conformational Disease Research:
ML346 is used as a research tool in the study of conformational diseases, where it promotes the folding of metastable proteins and helps understand the underlying mechanisms of protein misfolding and aggregation.

Check Digit Verification of cas no

The CAS Registry Mumber 100872-83-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,8,7 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100872-83:
(8*1)+(7*0)+(6*0)+(5*8)+(4*7)+(3*2)+(2*8)+(1*3)=101
101 % 10 = 1
So 100872-83-1 is a valid CAS Registry Number.

100872-83-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name	5-(4-methoxy-trans-cinnamylidene)-barbituric acid

1.2 Other means of identification

Product number	-
Other names	5-(4-Methoxy-trans-cinnamyliden)-barbitursaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100872-83-1 SDS

100872-83-1Upstream product

• 67-52-7 BARBITURIC ACID 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 637-69-4 4-Methoxystyrene 

100872-83-1Downstream Products

100872-83-1Relevant articles and documents

SHIKIMATE PATHWAY INHIBITORS AND THE USE THEREOF

-

Paragraph 0041;0042, (2015/05/26)

The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof. The present invention also provides a synergistic antibacterial composition containing compound

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