108852-90-0 Usage
Uses
Used in Oncology:
Nemorubicin is used as an anticancer agent for the treatment of tumors that are resistant to other chemotherapeutic agents, such as alkylating agents, topoisomerase II inhibitors, and platinum derivatives. Its unique mechanism of action through topoisomerase I inhibition and activity in cells with upregulated NER pathways make it a valuable option for patients with tumors that do not respond to conventional therapies.
Used in Liver Cancer Treatment:
Nemorubicin is used as a therapeutic agent for primary liver tumors or liver metastases due to its biotransformation in the liver into cytotoxic metabolites. This process contributes to the drug's high activity against liver cancer, offering a targeted treatment approach for patients with hepatic malignancies.
Used in Drug Resistance Overcoming:
Nemorubicin is used as a chemosensitizer to overcome drug resistance in cancer treatment. Its activity in cells with upregulated NER pathways allows it to effectively target tumors that have developed resistance to standard chemotherapeutic drugs, enhancing the overall efficacy of cancer treatment regimens.
Check Digit Verification of cas no
The CAS Registry Mumber 108852-90-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,8,5 and 2 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 108852-90:
(8*1)+(7*0)+(6*8)+(5*8)+(4*5)+(3*2)+(2*9)+(1*0)=140
140 % 10 = 0
So 108852-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C32H37NO13/c1-14-27(36)17(33-7-8-44-22(12-33)43-3)9-21(45-14)46-19-11-32(41,20(35)13-34)10-16-24(19)31(40)26-25(29(16)38)28(37)15-5-4-6-18(42-2)23(15)30(26)39/h4-6,14,17,19,21-22,27,34,36,38,40-41H,7-13H2,1-3H3/t14-,17-,19-,21-,22-,27+,32-/m0/s1
