19858-50-5Relevant articles and documents
cGAS ANTAGONIST COMPOUNDS
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Paragraph 0217; 0238; 0239, (2017/11/06)
Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS
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Page/Page column 172, (2015/11/27)
The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
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Page/Page column 58-59, (2011/08/03)
The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H-imidazo[2,1-b][1,3]oxazine (PA-824)
Kmentova, Iveta,Sutherland, Hamish S.,Palmer, Brian D.,Blaser, Adrian,Franzblau, Scott G.,Wan, Baojie,Wang, Yuehong,Ma, Zhenkun,Denny, William A.,Thompson, Andrew M.
experimental part, p. 8421 - 8439 (2011/02/21)
New heterocyclic analogues of the potent biphenyl class derived from antitubercular drug PA-824 were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both phenyl
Reduction of pyrimidine derivatives by LiAlH4
Yu-Xiu, Liu,Ming-Bo, Cui,Qi-Qi, Zhao,Qing-Min, Wang,Ying, Liu,Run-Qiu, Huang
, p. 490 - 493 (2008/09/21)
The reduction of ethyl 2-methylthio-(or 2-ethoxy)pyrimidine-5-carboxylate by LiAlH4 afforded ethyl 2-methylthio-(or 2-ethoxy)-1,6- dihydropyrimidine-5-carboxylate as the main product. Similarly, the reduction of 2-methylthio-(or 2-methoxy)pyrimidine-5-carboxamide by LiAlH4 gave 2-methylthio-(or 2-methoxy)-1,6-dihydropyrimidine-5-carbonitrile as main product.
