58194-26-6Relevant articles and documents
In a HPLC method for controlled for preparing high-purity of strontium ranelate method
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Paragraph 0044; 0047; 0050, (2017/07/14)
The invention discloses a method for preparing high-purity strontium ranelate through centralized control of the HPLC (High Performance Liquid Chromatography) method, and belongs to the field of pharmaceutical synthesis. The method comprises the following steps: (1) preparing a compound as shown in formula (II), namely, feeding a compound as shown in formula (I), tetrahydrofuran, anhydrous potassium carbonate and ethyl bromoacetate to a reaction kettle, and performing catalytic reaction through a catalyst, wherein the reaction endpoint is monitored through the HPLC; and (2) preparing a compound as shown in formula (III), namely, dropping a tetrahydrofuran solution in which the compound as shown in formula (II) is dissolved to inorganic aqueous alkali to saponify under the centralized control of the HPLC; performing reduced pressure distillation and filtering; regulating the pH (Power of Hydrogen) with hydrochloric acid; then adding a strontium chloride aqueous solution to obtain crude strontium ranelate which is characterized in that the purity is more than 99.7%, the single impurity is less than 0.1%, and the total impurity is less than 0.5%; and finally drying to obtain the targeted strontium ranelate. The strontium ranelate prepared by the method has the advantages that by means of the HPLC based centralized control, the optimal reaction time is determined and the refining and purifying steps are reduced; in addition, the method is simple in process, easy to control, high in product purity, less in waste liquid, low in energy consumption, relatively low in cost, and applicable to industrial production.
PROCESS FOR THE PREPARATION OF STRONTIUM RANELATE, INTERMEDIATE OR HYDRATES THEREOF
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Page/Page column 7, (2013/08/15)
The present invention relates to an improved process for the synthesis of strontium ranelate compound of formula I or its hydrates thereof. More particularly, the present invention relates to an economically viable and industrially feasible process for the preparation of strontium ranelate, intermediate or its hydrates thereof.
SUBSTANTIALLY PURE STRONTIUM RANELATE
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Page/Page column 19-20, (2011/10/31)
Provided herein is an improved, commercially viable and industrially advantageous process for the preparation of strontium ranelate, and its intermediates, in high yield and purity. Provided further herein is a highly pure strontium ranelate substantially free of impurities, and pharmaceutical compositions comprising highly pure strontium ranelate substantially free of impurities.
Synthesis of substituted thieno[2,3-b]pyrroles
Hongtao, Wei,Jin, Cai,Min, Sun,Min, Ji
, p. 236 - 238 (2008/02/07)
Thieno[2,3-b]pyrroles can be synthesized through three steps: Gewald synthesis, alkylation, and Thorpe-Ziegler cyclization. Diethyl 3,6-bis ((ethoxycarbonyl)methyl)-4-amino-6H-thieno-[2,3-b]pyrrole-2,5-dicarboxylate (13) has been obtained by one-pot method in DMF in good yield and high quality.
