7085-55-4Relevant articles and documents
Troxerutin compound
-
Paragraph 0050-0052; 0061-0065, (2020/01/14)
The invention discloses a troxerutin compound prepared by using an advanced on-line process control technology. The troxerutin compound is measured by X-ray powder diffraction, and a X-ray powder diffraction pattern expressed by a 2 diffraction angle shows characteristic diffraction peaks at the 2 of 8.15+/-0.2 degrees, 9.24+/-0.2 degrees, 12.31+/-0.2 degrees, 17.10+/-0.2 degrees, 17.92+/-0.2 degrees, 18.73+/-0.2 degrees and 23.45+/-0.2 degrees. The compound has the characteristics of high purity, low impurity content, good fluidity and good stability.
Preparation method of high-content troxerutin
-
Paragraph 0028; 0030-0031; 0034-0035; 0038-0039; 0042-0043, (2018/09/08)
The invention discloses a preparation method of high-content troxerutin and belongs to the technical field of pharmaceutical chemistry. The preparation method is characterized in that the preparationmethod of high-content troxerutin comprises the following steps: carrying out acetylation and purification of crude rutin used as a raw material, then hydrolyzing the crude rutin to obtain high-content rutin with a content being higher than 99.0%; reacting the high-content rutin under the catalysis action of a catalyst which is a third-generation PAMAM dendrimer to prepare troxerutin; and purifying the troxerutin to obtain the high-content troxerutin with a content being higher than 99.0%. According to the method, the high-quality rutin with the content being higher than 99.0% is used as the raw material, so that the high-content troxerutin crude drug is prepared; the method is low in cost and simple and convenient in steps, is economical and environmentally friendly, and is suitable for industrial production; the content of the prepared troxerutin can reach 99.0% or above.
A self-priming stirred autoclave preparation of troxerutin method
-
Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0031, (2017/06/29)
The invention discloses a method for preparing troxerutin by adopting a self-suction type stirred autoclave. The method comprises the following steps: adding raw materials namely rutin, ethylene oxide, a solvent namely methanol and a catalyst namely natural weakly-alkaline high-molecular compound chitosan into a self-suction type stirred autoclave, starting a digital control instrument, setting a temperature to be 70-90 DEG C, regulating a voltage to be 100V, setting a rotating speed to be 1000r/min, stirring and heating to reach a set temperature, and reacting for 3-6 hours; and stopping stirring after reaction is ended, rapidly cooling by using cold water, shutting down the digital control instrument, opening a reaction kettle, pouring out reaction liquid, adjusting a pH value of the poured reaction liquid to be 5-6 by using hydrochloric acid, performing suction filtration, adding a crystal seed into the reaction liquid subjected to suction filtration, standing for later crystallization, and filtering to obtain a product namely troxerutin. According to the method disclosed by the invention, the reaction raw materials are integrally added into the self-suction type stirred autoclave, so that material feeding steps can be simplified; and the adopted catalyst is natural weakly-alkaline high-molecular compound chitosan, so that the raw material is wide in source, and is natural, non-toxic and weakly-alkaline, and side reactions such as hydrolysis, oxidation and the like caused by strong alkaline catalysis can be avoided.
Preparation method of high-content troxerutin
-
Paragraph 0018-0026, (2017/07/19)
The invention discloses a preparation method of high-content troxerutin and belongs to the technical field of medicinal chemistry. According to the technical scheme, the preparation method of the high-content troxerutin comprises the specific steps that a coarse raw material product rutin is purified and refined to obtain high-content rutin higher than 99.0%; the high-content rutin reacts under the catalytic action of a catalyst natural polymer sodium alginate to prepare troxerutin; the troxerutin is purified to obtain the high-content troxerutin with the content higher than 98.0%. The preparation method refines the raw material rutin, water is adopted as a solvent in the refining process, the method is green and environmentally friendly, and the purity of the obtained rutin can be up to 99.0% or above. In addition, during troxerutin preparation, the natural polymer sodium alginate and appropriate reaction condition are adopted to make reaction reach the best level, and the high-content troxerutin crude drug with content higher than 98.0% can be obtained only by simply purifying the obtained product.
A high-purity of troxerutin preparation method
-
Paragraph 0013; 0014, (2017/07/01)
The invention discloses a preparation method of high-purity troxerutin. According to the preparation method of the high-purity troxerutin, the synthesis and refining processes of the troxerutin are improved; sodium methoxide or sodium ethoxide is selected as a catalyst, supercritical CO2 is selected for extraction and crystallization refining of the troxerutin, and finally, the troxerutin of which the yield and the purity both are greatly improved in contrast with a traditional process can be obtained.
High-purity troxerutin and preparation method thereof
-
Paragraph 0024; 0053-0059; 0062-0069; 0072-0079; 0083; 0084, (2017/08/29)
The invention provides high-purity troxerutin and a preparation method thereof, and relates to the technical field of medicinal chemistry and organic synthetic chemistry. The preparation method comprises a front etherification step, a complexation step, a post etherification step and a post-treatment step. The preparation method of the high-purity troxerutin is relatively low in cost, the high-purity troxerutin can be prepared and the method is suitable for industrial production.
Preparing method of 3',4',7'-troxerutin
-
Paragraph 0038; 0039, (2017/05/17)
The invention relates to a preparing method of 3',4',7'-troxerutin. The provided preparing method of 3',4',7'-troxerutin comprises the steps of mixing water and rutin at 10-30 DEG C, dropwise adding a catalyst potassium hydroxide solution under the condition of nitrogen protection stirring, slowly adding ethylene chlorohydrin, increasing the temperature to 60-70 DEG C, conducting a thermostatic reaction for 4-5 hours, and then adding potassium hydroxide to continue the reaction for 15-20 hours; the 3',4',7'-troxerutin is obtained after purification and refinement. The 3',4',7'-troxerutin prepared through the method is simple in production technology, and little oxidation hydrolysis by-product is generated, and the 3',4',7'-troxerutin is high in yield. By adopting water as a solution, purification solution formaldehyde can be recycled and utilized at the same time, thus the cost is sharply saved in large-scale production, meanwhile, the generation of waste materials is reduced, and economy and environmental friendliness of production is achieved.
Ultrasonic-assisted chemical synthesis Troxerution
-
Paragraph 0011-0014, (2017/01/23)
The invention relates to an ultrasonic-assisted synthetic method of troxerutin. Ultrasonic is used for organic chemical reactions in a new form of energy, so that many reactions which cannot be carried out or difficult to carry out in the past can be carried out smoothly; the ultrasonic is greatly superior to the traditional stirring and external heating methods as a convenient, quick, effective and safe synthetic technique. After the ultrasonic is used for synthesizing troxerutin, the reaction time is only 45min, in contrast, the reaction time of the traditional liquid phase method is 90-120min, therefore, the reaction time of the ultrasonic technique is reduced by half; besides, the reaction temperature is reduced by 30-40 DEG C, the etherification rate is increased by 20%, and the etherification rate can be 95%. Furthermore, the ultrasonic technique is simple in process and easy for industrial production.
PREPARATION METHOD OF TRIHYDROXYETHYL RUTOSIDE
-
Paragraph 0093; 0094, (2016/05/02)
The present invention relates to a preparation method of trihydroxyethyl rutoside. In the method, rutin is firstly prepared into 7-monohydroxyethyl rutoside with a purity of greater than or equal to 98% by weight, and then 7-monohydroxyethyl rutoside is hydroxyethylated to give troxerutin having less than 2% of non-hydroxyethylated rutoside derivatives. The amount of 7,3′,4′-trihydroxyethyl rutoside in troxerutin is more than 80% by weight. The product is further purified so that 7,3′,4′-trihydroxyethyl rutoside with a purity of greater than or equal to 98% by weight could be obtained.
PREPARATION METHOD OF TRIHYDROXYETHYL RUTOSIDE
-
Paragraph 0083; 0085; 0086, (2017/01/05)
The present invention refers to tree hydrocyethylmetacrylate base toe side relates to manufacturing method of (trihydroxyethyl rutoside), said method (rutin) routine first content is detected to be compared with a 98% or more 7- base toe side hydrocyethylmetacrylate mono (7-monohydroxyethyl rutoside) after prepared with, continues to 7-mono hydrocyethylmetacrylate of hydrocyethylmetacrylate for on base toe side non by performing a photo lithography process (hydroxyethylated) (-glycidyl) 2% impurities derivatives base toe side of hydrocyethylmetacrylate [...] be smaller than present, obtains and makes (troxerutin), during said [...] 7,3 ', 4' -80% hydroxyethyl base toe side weight content and present, said continues product 98% or more weight content which comprises purifying an 7,3 ', 4' -may yield an hydroxyethyl base toe side.
