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藥物化學(xué)大辭典
交聚血紅蛋白
英文品名 hemoglobin raffimer
名稱來(lái)源 p-INNList-89,2003;r-INNList-51,2004;
化學(xué)表述 the polyaldehyde [(2R,4S,6R,8R,11S,13R)-1,14-dihydroxy-4-hydroxymethyl-3,5,7,10,12-pentaoxatetradecane-2,4,6,8,11,13-hexacarbaldehyde] derived from raffinose [β-D-fructofuranosyl α-D-galactopyranosyl-(1→6)-α-D-glucopyranoside] by treatment with sodium periodate is reacted with human hemoglobin A0 at the 2,3-DPG binding pocket. Both 55% is polymerised.intermolecular and intramolecular crosslinking occurs. This product is reduced to generate covalent amine bonds with >95% crosslinked hemoglobin of which about 55% is polymerised.
CA登記號(hào) 197462-97-8
結(jié) 構(gòu) 式
品種類別 血液系統(tǒng)>血液代用品和血漿蛋白成分
ATC編碼 B05AA09;
參考文獻(xiàn) MI(4666)
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